personnel profile
 Peter M. Pinsky
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| Title: | Professor |
| Department(s): | Mechanical Engineering, Civil and Environmental Engineering by courtesy |
| Location: | Durand 221 |
| Mail Code: | 4040 |
| Phone: | 650.723.9327 650.723.4121 |
| Fax: | 650.723.1778 |
| E-mail: |
pinsky@stanford.edu |
| Administrator: | Doreen E. Wood |
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Research Statement
Pinsky studies computational aspects of structural and solid mechanics, applying the finite element method to nonlinear and dynamical problems. Topics of special interest include computational methods for acoustic and electromagnetic wave propagation, structural acoustics, ocular biomechanics, computational methods for semiconductor device and process simulation, atomistic-continuum multiscale simulation of materials, and iterative and parallel solution methods for large-scale problems.
| Research Projects |
| Connective Tissue Elasticity: Bridging the Scales Between Chemical Morphology and Engineering Models |
Summary:
Connective Tissue Elasticity: Bridging the Scales Between Chemical Morphology and Engineering Models
Detail:
Connective tissues (CTs), which define bodily shape, must respond quickly, robustly and reversibly to deformations caused by internal and external stresses while performing a variety of mechanical functions in the body: tendon transmits tension from a contracting muscle; articular cartilage forms a resilient coating on the ends of the bones in synovial joints, etc. These mechanical functions derive directly from the structure and composition of the extracellular matrix (ECM). If, for example, the chemical composition of the ECM changes during normal physiological or pathological processes, then the properties of the tissue will also change – consider the remarkable changes in mechanical properties of the uterine cervix in pregnancy which allows it to dilate during labor. Less dramatic changes occur in most tissues during aging; mechanical failure of CTs is implicated in common rheumatic conditions such as osteoarthritis. In this project we seek to take a first step toward a new rheology of CT based on experimental measurements and predictive multiscale modeling. This integrative approach aims to create a framework for understanding and describing CT elasticity and strength (failure) based on molecular mechanisms propagated through the tissue’s hierarchical structures. The proposed studies intimately connect the disciplines of biology, chemistry, mechanics and materials science and the proposed framework could be important for modeling normal and pathological tissue with many clinical applications; for providing guiding principles for growing and modifying de novo ECM, and for facilitating the rational design of strategies to generate mechanically functional replacement tissues.
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Display All Research Projects
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| Degree |
Discipline |
Year |
School |
| PhD |
Civil Engineering |
1981 |
University of California, Berkeley |
| M.Sc |
Civil Engineering |
1971 |
University of Toronto |
| B.Sc. (Hons) |
Civil Engineering |
1969 |
University of Wales, Swansea |
| Publication Title | Author(s)/Speaker(s) | Open Document |
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Simulating and interpreting Kelvin probe force microscopy images on dielectrics with boundary integral equations
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Y. Shen, D.M. Barnett and P.M. Pinsky |
Sci Instruments_1429.pdf |
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Recovery of shear modulus in elastography using an adjoint method with B-spline representation
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Pinsky, PM, et. al. |
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A 3D model of muscle reveals the causes of nonuniform strains in the biceps brachii
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Pinsky, PM, et. al. |
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Finite element modeling of coupled diffusion with partitioning in transdermal drug delivery
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Pinsky, PM, et. al. |
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Title:
Simulating and interpreting Kelvin probe force microscopy images on dielectrics with boundary integral equations
Author(s):
Y. Shen, D.M. Barnett and P.M. Pinsky
Journal:
Review of Scientific Instruments
, Volume 79
, Number 023711
Date Published:
2008
Title:
Recovery of shear modulus in elastography using an adjoint method with B-spline representation
Author(s):
Pinsky, PM, et. al.
Journal:
Finite Elements in Analysis and Design
Date Published:
2005-4
Title:
A 3D model of muscle reveals the causes of nonuniform strains in the biceps brachii
Author(s):
Pinsky, PM, et. al.
Journal:
Journal of Biomechanics
Date Published:
2005-4
Title:
Finite element modeling of coupled diffusion with partitioning in transdermal drug delivery
Author(s):
Pinsky, PM, et. al.
Journal:
Annals of Biomedical Engineering
Date Published:
2005-10
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